Mental health encompasses emotional, cognitive, psychological, and social well-being. It affects how humans think, feel, learn, work, make decisions, and build relationships. The importance of mental health to individual well-being, as well as to social and economic progress, is becoming more widely recognized.1 Mental health affects physical health (including nutrition, substance abuse, outcomes for infectious diseases, and incidence of noncommunicable diseases); child health and development; education outcomes; and workforce participation, among others. Evidence also shows that mental health conditions are higher among populations exposed to environmental stressors such as extreme poverty; war and conflict; food insecurity; high levels of community violence, including gender-based violence (GBV); and stigma and discrimination.2,3,4 Crucially, mental health also affects service providers, community workers, and activists who drive development progress. Taken together with the growing evidence of an emergent global mental health crisis,5,6,7,8 these factors make it clear that mental health is intricately tied to USAID’s ability to meet its development objectives across sectors and should be seen as an intersectional priority for the Agency.