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अथवा गुगल अनुवाद प्रयोग:  

Newcastle disease vaccine virus I-2 fails to acquire virulence during repeated passage in vivo

https://pmc.ncbi.nlm.nih.gov/articles/PMC8595976/

Bisschop SPR, Peters A, Domingue G, Pearce MC, Verwey J, Poolman P. Newcastle disease vaccine virus I-2 fails to acquire virulence during repeated passage in vivo. Gates Open Res. 2021 Dec 23;5:76. doi: 10.12688/gatesopenres.13212.3. PMID: 34859194;  PMCID: PMC8595976.

Background This study determined whether the naturally attenuated, thermotolerant Newcastle disease vaccine virus I-2 could acquire virulence after five in vivo passages through SPF chickens.

Conclusions: These data, the issue of low passage titres with little or no virus isolation from brain tissues and the genomic copy approach suggest a need to amend Ph. Eur. v9.0 04/2013:0450, 2013 for naturally attenuated, low pathogenicity vaccine viruses such as I-2. From an international regulatory perspective, the study provides further definitive data demonstrating that Newcastle disease vaccine virus I-2 is safe for use.

Keywords: Newcastle Disease, I-2; passage, acquired virulence, European Pharmacopoeia, village chickens

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