Molecular docking of ethanol extracts of katuk leaf (Sauropus androgynus) on functional proteins of severe acute respiratory syndrome coronavirus 2

Annisa Camellia Makati, Aghnia Nabila Ananda, Jasmine Aisyah Putri, Siti Feritasia Amellia, Bambang Setiawan,
Molecular docking of ethanol extracts of katuk leaf (Sauropus androgynus) on functional proteins of severe acute respiratory syndrome coronavirus 2,
South African Journal of Botany,
Volume 149,
2022,
Pages 1-5,
ISSN 0254-6299,
https://doi.org/10.1016/j.sajb.2022.04.044.
(https://www.sciencedirect.com/science/article/pii/S0254629922002058)
Abstract: ABSTRACT
The Katuk plant (Sauropus androgynus) is a plant species that is widely found in Southeast Asia. Its leaves that can be consumed to increase breast milk production. The people of South Kalimantan recognize use katuk leaves as a special food called tapai green sticky rice. Katuk leaves have antibacterial and antiviral properties, and they have high flavonoid content (Andarwulan et al., 2010). Flavonoids have low systemic toxicity, and they can synergize with conventional drugs. Moreover, flavonoids are "pleiotropic" compounds, which means that their functional groups can interact with different cellular targets and inhibit several antiviral molecular pathways (Russo et al., 2020). However, the anti-COVID-19 effect of katuk (Sauropus androgynus) leaves has not been revealed. Therefore, we conducted this study to investigate the potential of the flavonoid group of active compounds from katuk leaves (Sauropus androgynus) as an antiviral agent for COVID-19 using target proteins for COVID-19 drugs.
Keywords: Bioinformatics; COVID-19; flavonoids; herbal; SARS-CoV-2