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The U.S. Government’s Global Food Security Strategy (GFSS) 2022–2026 calls on the U.S. Government and its implementing partners to foster inclusive agricultural growth for small-scale producers, small- andmedium-sized enterprises (SMEs), and poor households, while increasing access to safe, healthy foodsand benefiting the environment. Programming can catalyze this inclusive growth by using a marketsystems development (MSD) approach that fosters more competitive, inclusive, and resilient marketsystems. The MSD approach, defined in the U.S. Agency for International Development’s (USAID)AFramework for Inclusive Market System Development,is relevant to agricultural and nonagriculturalareas, including food systems and water and sanitation services, making it a powerful framework forprogramming across GFSS objectives. This guidance clarifies concepts and definitions, describes howusing an inclusive market systems approach in programming can advance the GFSS, provides relevantactivity examples, and identifies resources for design and implementation.